Name: Souvik Mukherjee

E-mail: sm2.bmgc@nibmg.ac.in

Designation: Assistant Professor

Highest Educational Qualification: Ph.D.

 

 

 

Research

I am interested in studying the genomic and metagenomic factors that contributes to the predisposition and progression of chronic, inflammatory diseases in humans. I am also interested in studying the population genetics and molecular evolution of host-pathogen interacting genes across human populations.

 

Ongoing Projects

Genomic characterisation of Skin surface Microbiome across different skin types in Humans

 

Project Co-ordinators

Prof. Partha P. Majumder, Director, National Institute of Biomedical Genomics, Kalyani

Dr. Souvik Mukherjee, Assistant Professor, BioMedical Genomics Centre, Kolkata

Dr. Amit Charabortty, R&D Director, Unilever Research Foundation, Bangalore                

Dr. Rupak Mitra, Senior Research Scientist, Unilever Research Foundation, Bangalore

                         

The skin is a natural habitat for trillions of micro-organisms collectively termed as the skin microbiome. Potential challenges in skin microbiome research are mostly related to its impact in skin health and disease. In this study our major objective is to assess the importance of the skin microbiome with respect to skin health and integrity by evaluating both the temporal variation and impact of topical cosmetic products in different skin types in humans.

 

Metagenomic Characterisation of the Cutaneous Microbiome Associated with Major Immunogenetic Subtypes of Psoriasis in India

(Extramural funding by DST-Young Scientist Scheme)

 

The project aims to identify specific microbiome signatures in the skin of Psoriasis affected patients with and without genetic predispostion, differential disease severity and other clinical factors. The microbiome patterns thus identified will serve as an important addition to the already known factors for Psoriasis susceptibility. This will serve as the basis for undertaking a longitudinal study to evaluate the therapeutic efficacy and episodic relapses that are the major hurdles in the treatment of psoriasis.

 

Diabetic Foot Ulcer Microbiome Contribution in Biofilm formation, Antibiotic Resistance and Wound healing

Project Co-ordinators

Dr. Souvik Mukherjee, Assistant Professor, BioMedical Genomics Centre, Kolkata

Prof. (Dr.) Satinath Mukherjee, Professor, IPGME&R and SSKM Hospital, Kolkata

Dr. Poulami Mukherjee, DBT-Research Associate, BioMedical Genomics Centre, Kolkata

 

Diabetes mellitus is a major and rapidly increasing health problem worldwide. Foot disorders, including Diabetic Foot Ulcers (DFU) are a major source of morbidity and a leading cause of hospitalization for persons with diabetes. Targeting microbial populations to promote healing and deter infection-related complications might be a novel treatment option. In this study our major objective is to determine the microbiome profiles in both superficial and chronic DFUs associated with biofilm formation, antibiotic resistance and wound healing and comparison between culturable and non-culturable bacterial populations.

 

Summer Interns Trained

Shankha Nath, Dept. of Genetics, C.U. (Jun-Aug 2014), Biotech-RISE Intern (Jun-Aug 2015)

Amit Sarkar, Dept. of Biochemistry, C.U. (Jun-Aug 2015)

Joydeep Ghosh, Dept. of Biophysics and Molecular Biology, C.U. (Jun-Aug 2015)

 

Selected Publications

 

Mukherjee S, Ganguli D and Majumder PP. (2014) Global Footprints of Purifying Selection on Toll-Like Receptor Genes Primarily Associated with Response to Bacterial Infections in Humans. Genome Biology and Evolution. 6551–558.

 

Mukherjee S, Ganguli D and Majumder PP.(2013) Discovery of  High Frequencies of the Gly-Ile Haplotype of TLR4 in Indian Populations Requires Reformulation of the Evolutionary Model of its Maintenance. Infection Genetics and Evolution 19223-225.

 

India Project Team of International Cancer Genome Consortium. (2013) Mutational landscape of gingivo-buccal oral squamous cell carcinoma reveals new recurrently-mutated genes and molecular subgroups. Nature Communications 42873.

 

Mukherjee S, Sarkar-Roy N, Wagener DK, Majumder PP. (2009) Signatures of natural selection are not uniform across genes of innate immune system, but purifying selection is the dominant signature. Proceedings of the National Academy of Sciences, USA 1067073-7078.

 

Bairagya BB, Bhattacharya P, Bhattacharya SK, Dey B, Dey U, Ghosh T, Maiti S, Majumder PP, Mishra K, Mukherjee S, Mukherjee S, Narayanasamy K, Poddar S, Sarkar-Roy N, Sengupta P, Sharma S, Sur D, Sutradhar D, Wagener DK. (2008) Genetic Variation and Haplotype Structures of Innate Immunity Genes in Eastern India. Infection, Genetics & Evolution 8360–366.
Authorship is alphabetical)

* Corresponding Author