Name: Priyadarshi Basu

E-mail: pb1@nibmg.ac.in

Designation: Assistant Professor, NIBMG

Highest educational Qualification: Ph.D.

 

 

 

Research

My laboratory is interested in studying the genomic and epigenomic causes of Non-alcoholic fatty liver disease (NAFLD) in Indian populations. NAFLD is an umbrella term which describes a range of related and progressive disorders (simple steatosis to NASH, cirrhosis and hepatocellular carcinoma), characterized by insulin resistance. NAFLD is emerging as the major cause of liver disease in India, with a prevalence of 9% in rural India to 32% in the general population. The rural Indian phenotype is also quite distinct from the Western phenotype, which is associated with obesity.

 

Ongoing Project

Genomic and Epigenomic analyses of Non Alcoholic Fatty Liver Disease (NAFLD) in the Indian population

 

Project Co-ordinators

Prof Abhijit Chowdhury                                   PI

Dr. Priyadarshi Basu                                       Co-PI

Dr. Analabha Basu                                          Co-I

Ankita Chatterjee                                           Research Scholar

 

In this project we are undertaking genome-wide association analyses of NAFLD, which will complement our understanding of this novel Indian trait, which is quite distinct from the Western phenotype, which is associated with obesity. Epidemiologic evidence indicates that NAFLD in lean individuals might be a consequence of the transitional nutritional features or malnutrition in these individuals. We think that these factors might have a huge influence on the methylome of these individuals. Therefore, a second objective of my laboratory is to examine the roles that epigenetic factors play in NAFLD susceptibility and whether there is any interaction with genetic factors.

 

 

Selected Publications

 

Basu P, Lung T, Lemsaddek W, Giang Sargent T, Williams DC Jr, Basu M, Redmond LC, Lingrel JB, Haar JL, Lloyd JA. (2007) EKLF and KLF2 have compensatory roles in embryonic e-globin gene expression and primitive erythropoiesis, Blood. 1103417-3425.

 

Basu P, Morris PE, Haar J, Wani MA, Lingrel JB, Gaensler KML and Lloyd JA. (2005) KLF2 is essential for primitive erythropoiesis and regulates the human and murine embryonic β–like globin gene in vivo, Blood. 1062566-71.

 

Basu P, Sargent TG, Redmond LC, Aisenberg JC, Kransdorf EP, Wang SZ, Ginder GD and Lloyd JA. (2004) Evolutionary conservation of KLF transcription factors and functional conservation of human β-globin gene regulation in chicken, Genomics. 84, 311-319.

 

Basu P, Majumder PP, Roychoudhury S and Bhattacharyya NP. (2001) Haplotype analysis of genomic polymorphisms in and around the myotonic dystrophy locus in diverse populations of India, Human Genetics. 108, 310-317.

 

Bhattacharyya NP, Basu P, Das M, Pramanik S, Banerjee R, Roychoudhury S and Majumder PP. (1999) Negligible male gene flow across ethnic boundaries in India, revealed by analysis of Y-chromosomal DNA polymorphisms, Genome Research. 9, 711-719.