Name: Nitai Pada Bhattacharyya

E-mail: npb1.bmgc@nibmg.ac.in

Designation: Director

Highest Educational Qualification: Ph.D.

 

Research

Human Genetic Disease, Genome/Disease Biology, Gene Regulation

Engaged in coordination and defining the biomedical research by clinicians in medical institutions and basic scientists in the centre

Ongoing Project

Extramural funded project entitled “Deregulation of micro RNA in cell and animal models of Huntington’s disease role of altered micro RNA in neuronal differentiation and cell cycle regulation” (No.BT/PR7185/ MED/30/910/2012 dated 2.8.2013).

The major goals of the proposed project are to identify the altered micro RNAs (miRNAs) globally in Huntington’s disease (HD) models and implication of miRNAs in biological processes like neuronal cell cycle, differentiation and ubiquitin-proteasome system. To achieve the goals we proposed (i) To identify the miRNAs altered in cell and animal models of HD by RNA sequencing using "next generation DNA sequencer", (ii) to identify target proteins of the deregulated miRNAs involved in cell cycle, neuronal differentiation and ubiquitin-proteasome system and validate experimentally and (iii) to identify the role of miRNA in neuronal cell cycle and differentiation and ubiquitin proteasomal system (UPS) using STHdh111/111 and STHdh7/7 cells, a cell model of HD.

Selected Publications

Choudhury KR, Das S, Bhattacharyya NP. (2016) Differential proteomic and genomic profiling of mouse striatal cell model of Huntington's disease and control; probable implications to the disease biology, J Proteomics, 132, 155-166.

Das S, Bhattacharyya NP. (2015) Heat Shock Factor 1-Regulated miRNAs Can Target Huntingtin and Suppress Aggregates of Mutant Huntingtin, Microrna, 185-193.

Das E, Bhattacharyya NP. (2014) MicroRNA-432 contributes to dopamine cocktail and retinoic acid induced differentiation of human neuroblastoma cells by targeting NESTIN and RCOR1 genes. FEBS Letters. 588, 1706-1714.

Basu M, Bhattacharyya NP, Mohanty PK (2013)Comparison of modules of wild type and mutant Huntingtin and TP53 protein interaction networks implications in biological processes and functions. PLoS One. 8, e64838.

Sinha M, Mukhopadhyay S, Bhattacharyya NP. (2012) Mechanism(s) of alteration of micro RNA expressions in Huntington's disease and their possible contributions to the observed cellular and molecular dysfunctions in the disease. Neuromolecular Med. 14, 221-243.