Name: Mitali Chatterjee

E-mail: ilatim@vsnl.net; ilatimc@gmail.com

Designation: Professor, Dept. of Pharmacology, IPGME&R, Kolkata

Adjunct Professor, BioMedical Genomics Centre, Kolkata

Highest Educational Qualification: MD, Ph.D., FNASc, MAMS

 

 

Research

Immunopharmacology

 

Ongoing Projects

 

Genetic Variations in the Toll-Like Receptor Genes in Visceral Leishmaniasis and Post Kala-azar Dermal Leishmaniasis Patients from Eastern India
A Transcriptome approach to identify clinico-immunological determinants of Post Kala-azar Dermal Leishmaniasis” Approved, Dept. of Health Research, Govt. of India
Therapeutic effectiveness of allylpyrocatechol (APC) in experimental models of arthritis. 2012-2016, DBT, Govt. of India
Malabaricones as potential anticancer agents, 2013-2016, DST, Govt. of West Bengal

 

Toll-Like Receptors (TLRs) are an important class of pattern recognition receptors (PRRs) that are directly involved in host-pathogen interactions in humans. These genes are therefore important candidates for natural selection in the context of infectious diseases. Specific alleles and haplotypes in these genes are previously shown to increase the susceptibility for various infectious diseases and hence show a definite pattern of allele frequency distributions globally. In this study, we sought to understand the nature and extent of genetic variations in the Toll-Like Receptor (TLR) genes in a hospital-based cohort of VL and PKDL patients to understand the relevance of the specific haplotypes in the context of infectious diseases in the Indian population.

 

Selected Publications

 

Mukherjee S, Mukhopadhyay D, Ghosh S, Barbhuiya JN, Das NK, Chatterjee M. (2016) Decreased Frequency and Secretion of CD26 Promotes Disease Progression in Indian Post Kala-azar Dermal Leishmaniasis. J Clin Immunol, 36(1)85-94.

 

Mukhopadhyay D, Mukherjee S, Roy S, Dalton JE, Kundu S, Sarkar A, Das NK, Kaye PM, Chatterjee M. (2015) M2 polarization of monocytes-macrophages is a hallmark of Indian Post kala-azar dermal leishmaniasis. PLoS Negl Trop Dis, 9:e0004145.

 

Mukherjee S, Mukhopadhyay D, Braun C, Barbhuiya, JN, Das N, Chatterjee U, von Stebut-Borschitz E, Chatterjee, M. (2015) Decreased presence of Langerhans cells is a critical determinant for Indian Post kala-azar dermal leishmaniasis. Exp Dermatol, 24:232-4.

 

Roy S, Mukhopadhyay D, Mukherjee S, Ghosh S, Kumar S, Sarkar K, Pal D, Bhowmik P, Mandal K, Modak D, Guha SK, Pramanik N, Goswami RP, Saha B, Chatterjee M. (2015) A defective oxidative burst and impaired antigen presentation are hallmarks of human Visceral Leishmaniasis. J Clin Immunol, 35: 56-67.

 

Manna A, De Sarkar S, De S, Bauri AK, Chattopadhyay S, Chatterjee M. (2015) The variable chemotherapeutic response of Malabaricone-A in leukemic and solid tumor cell lines depends on the degree of redox imbalance. Phytomed, 22:713-23.